Semaglutide vs. Tirzepatide: Key Differences to Discuss With a Clinician
The main difference
Semaglutide acts on one hormone receptor: GLP-1.
Tirzepatide acts on two: GLP-1 and GIP.
Both are available as injections, and semaglutide is also available in an oral form. Which option (if any) fits you depends on your health history, goals and other medications — a decision for a licensed clinician.
Side effects to know about
For both, side effects are mostly gastrointestinal (nausea, vomiting, diarrhea, constipation, abdominal pain). Serious risks include possible thyroid C-cell tumors, pancreatitis, gallbladder disease, low blood sugar when used with insulin or sulfonylureas, and kidney problems. In an emergency, call 911.
Cost
Prices depend on the medication your clinician prescribes and are always shown before you pay. No insurance is needed.
About compounded medications
Compounded semaglutide and tirzepatide are prepared by state-licensed pharmacies. They are not FDA-approved and are not reviewed by the FDA for safety, effectiveness or quality.
Next step
Check my eligibility → — a licensed clinician reviews your answers and decides.
Important Safety Information: read here. Individual results vary. Adults 18+ in eligible U.S. states.
