Safety
Important Safety Information
Last updated: October 24, 2026
This page covers the compounded medications a licensed clinician may prescribe through GLP: compounded semaglutide and compounded tirzepatide. Compounded medications are not FDA-approved and are not reviewed by the FDA for safety, effectiveness, or quality.
Prescription required
A licensed clinician reviews your assessment and prescribes only if it's appropriate for you — and tells you plainly if it isn't. Submitting an assessment is not a guarantee of treatment. You don't choose your medication.
About compounded medications
GLP does not manufacture compounded medications. Compounded medications are not FDA-approved and are not reviewed by the FDA for safety, effectiveness, or quality. They are prepared by state-licensed pharmacies.
Compounded semaglutide
Who should not take semaglutide?
Semaglutide is contraindicated in anyone with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, and in anyone who has had a serious allergic reaction to it. Pregnancy, planning a pregnancy and breastfeeding rule treatment out. A history of pancreatitis or gallbladder disease, significant gastrointestinal conditions, type 1 diabetes, and medications that affect blood sugar all call for clinical judgment. None of these lists is exhaustive; that is what the assessment screens for, and why a clinician can say no.
What side effects does semaglutide cause?
The most common side effects of semaglutide are gastrointestinal: nausea, vomiting, diarrhea, constipation, abdominal pain and reduced appetite. They tend to appear in the early weeks and after a dose increase, which is why the dose is stepped up slowly and can be held when a step is not being tolerated.
Semaglutide may cause serious side effects, including possible thyroid C-cell tumors, pancreatitis, gallbladder disease, low blood sugar when combined with insulin or sulfonylureas, kidney problems with dehydration, and complications of diabetic retinopathy. Your clinician screens for these before prescribing. Message your care team about any symptom that concerns you; for a medical emergency, call 911.
Prescribed through GLP as: Semaglutide Injections, Oral Semaglutide, Semaglutide Microdose Injection.
Compounded tirzepatide
Who should not take tirzepatide?
Tirzepatide is contraindicated in anyone with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, and in anyone who has had a serious allergic reaction to it. Pregnancy, planning a pregnancy and breastfeeding rule treatment out. A history of pancreatitis or gallbladder disease, significant gastrointestinal conditions, type 1 diabetes, and medications that affect blood sugar all call for clinical judgment. None of these lists is exhaustive; that is what the assessment screens for, and why a clinician can say no.
What side effects does tirzepatide cause?
The most common side effects of tirzepatide are gastrointestinal: nausea, diarrhea, reduced appetite, vomiting, constipation, indigestion and abdominal pain, along with injection-site reactions. They tend to appear in the early weeks and after a dose increase, which is why the dose is stepped up slowly and can be held when a step is not being tolerated.
Tirzepatide may cause serious side effects, including possible thyroid C-cell tumors, pancreatitis, gallbladder disease, low blood sugar when combined with insulin or sulfonylureas, kidney problems with dehydration, and complications of diabetic retinopathy. Tirzepatide can also reduce how well oral birth control works around the start of treatment and after each dose increase, so tell your clinician everything you take. Message your care team about any symptom that concerns you; for a medical emergency, call 911.
Prescribed through GLP as: Tirzepatide Injections, Tirzepatide Microdose Injection.
Microdose programs
Lower-than-standard dosing is not an FDA-approved regimen and has no established evidence base of its own. Side effects can occur at any dose, and a smaller amount is not a guarantee of fewer. The contraindications and side effects above apply at every dose.
Reporting side effects
Message your care team about any symptom that concerns you; for a medical emergency, call 911. You can also report side effects to the FDA’s MedWatch program at www.fda.gov/medwatch or 1-800-FDA-1088.
This page is general information, not medical advice, and does not list every possible side effect. Whether any medication is appropriate for you is a decision for a licensed clinician who has reviewed your health history. Availability, pricing, and treatment options vary by state.